Realtime 3D Label-Free Cell Imaging and Visualisation


Tomocube’s revolutionary Holotomographic (3D holographic) microscopy opens new era for label-free Live-Cell Imaging. This technique utilizes optical diffraction tomography (ODT), which enables users to quantitatively and noninvasively investigate biological cells and thin tissues. ODT reconstructs the 3D refractive index (RI) distributions of live cells and by doing so, provides structural and chemical information about the cell including dry mass, morphology, and dynamics of the cellular membrane.

           Holotomographie with Tomocube                                                 HT-X1 Introduction


Click and Learn more about Different Tomocube-Products




                            Multi-Well-Analysis with HT-X1



Product Features

  • High resolution, high contrast and high sensitivity
  • Large-field detection
  • Programmable multi-well analysis
  • Laser autofocus for plate-to-plate reproducibility
  • Low-noise, stain-free imaging without further calibration steps
  • Quantitative Bioimaging
  • Integrated incubation for long-term time-lapse
  • Integrated 5-channel FL light engine
  • Correlative holotomography with 3D fluorescence
  • True multidimensional imaging across time, space and modality



                HT-1H Holotomographic Microscopy
        HT-2H Holotomographic Microscopy
        with 3D Fluorescence Imaging Capability



Product Features

  • Fast and label-free imaging
  • High-resolution (super-resolution) without moving parts
  • Long-term live-cell imaging
  • Negligible photo damage due to low power laser
  • Real-time analysis with quantitative data
  • Upgradeable with 3D fluorescence imaging capability (correlative HT with FL)




                 HT Microscopy Concept



Lipid Quantification




Bacteria Analyses


                K. Pneumoniae Ampicillin treated
             K. Pneumoniae Control


                                                                 Phase Separation



Further Applications


Hematology: Malaria infection, Sickle cell identification, Blood analysis

Microbiology: Bacteria classification, Microorganism imaging, Lipid content test of microorganism

Immunology: White blood cell classification, Immune response

Nanotechnology: Nanoparticle imaging, Cell organelle tagging with nanoparticle

Cell biology: Intracellular trafficking, Cell division, Live cell imaging, Quantification, Cellular structure analysis


































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